VESIsorb, The Nano-Colloid Nutrient Delivery Breakthrough
The VESIsorb technology
uses a patented mix of water-compatible but oily molecules to combine
with the poorly water soluble CoQ10, DHA and EPA molecules and convert
them into an oily molecular complex. Once this mixture is exposed to
water, as occurs when they are consumed by mouth, the complex
self-reorganizes into ultra-microscopic fluid colloidal droplets. These
are termed nano-colloids, being typically less than 100 nanometers in
diameter (1 nanometer being one millionth of one millimeter). They
dissolve the actives into the aqueous phase, from which these can
diffuse into close proximity with the intestinal lining cells and more
readily become absorbed.
Coenzyme Q10 (Ubiquinone)
is a vitamin-like nutrient, currently classified as “conditionally
essential” for health. The body can make limited amounts of CoQ10, but
additional supplies from the diet seem necessary to good health. CoQ10
deficiencies are well documented and have wide-ranging negative effects
on health. Oral CoQ10 supplementation sufficient to raise
its blood levels into normal range will often substantially restore
Gene mutations that impair the body’s synthesis of CoQ10 can cause
severe problems from birth (primary CoQ10 deficiency). These cases
typically have severe fatigue that often coexists with limitations on
the heart, skeletal muscle, kidney and brain. In such cases,
ample supplementation with CoQ by mouth can raise its blood levels,
replenish CoQ10 in the tissues and thereby revitalize tissue functions.
Secondary CoQ10 deficiencies can result from intensive physical exercise, exposures to oxidative toxins,
or consumption of statins and certain other pharmaceutical drugs.1 The
use of CoQ supplements with poor bioavailability often is insufficient
to correct such deficiencies and has unreliable benefit from one
individual to another. The VESIsorb technology is such an efficient
delivery system that it virtually guarantees blood CoQ10 will be
elevated into the range necessary for resolving deficiency.
Irreplaceable for Cell Energy Production
is literally “the spark of life” because it is indispensable for the
generation of life energy as ATP (adenosine triphosphate).
The cell’s energy generators are its 500-1000 mitochondria, each
demarcated inside the cell by double membranes. Though the entire cell
membrane network carries CoQ10, mitochondria have by far the highest
unit CoQ10 content and no other nutrient can substitute for CoQ10’s
Relying on CoQ10, the mitochondria generate more than 90 percent of the body’s ATP.
Within the core of the inner mitochondrial membrane, molecules of CoQ10
are continually moving back and forth, rapidly shuttling electrons
between large protein catalysts that altogether generate ATP. DHA and EPA give to the membrane core a flexibility (semi-fluid state) that facilitates these ultra-rapid migrations of CoQ10.
Mitochondrial efficiency tends to decline with age.
Mitochondrial decline typically features lowered ATP generation
capacity, linked to declining function of the brain, heart, skeletal
muscles, and other organs. Conversely, oral supplementation with CoQ10
to raise its blood levels above certain thresholds can have valuable
benefits for individuals with fatigue problems or with other problems
related to poor mitochondrial performance.
Potent and Unique Antioxidant Protectant
is also a potent antioxidant, able to readily donate electrons to block
“free radical” and other oxidative attack on cell membranes. As an
antioxidant CoQ10 seems especially important for the mitochondrial
membranes. This could be a very important contribution to
health, because the very same “oxidative phosphorylation” process that
generates ATP in the mitochondria also creates a continuous leakage of
oxygen free radicals that can create substantial cell damage unless
restrained by antioxidant defense. Many experts believe oxygen free
radical damage could be the ultimate restraint on the human
CoQ10 also helps protect the rest of the cell’s labyrinthine system
of membranes, even helping to conserve the vitamin E of membranes by
recycling it from the oxidized to the antioxidant reduced form. There is good evidence for antioxidant synergy between CoQ10 and vitamin E.1
As vitamin E or total antioxidant capacity falls within the membranes,
their CoQ10 content tends to rise, perhaps as a compensatory adaptation.
CoQ10 seems to be centrally involved in maintaining the membrane’s
“redox poise”, a delicate balance between oxidation and reduction that
is important for good health.
Protects the Heart and Blood Vessels
provides key support for the heart in its crucial function as the
body’s mechanical pump, as concluded from two “meta-analyses” that
separately pooled data from multiple clinical trials.
CoQ10’s high degree of importance for the beating heart is consistent
with the heart muscle fibers having the highest density of mitochondria
and the highest CoQ10 concentration of any tissue.
CoQ10 also protects the blood vessels and can boost their performance.1
In its role as energy catalyst CoQ10 helps sustain the endothelium, the
highly active single layer of flattened cells that line the inner blood
vessel walls. As an antioxidant, CoQ10 protects the circulating LDL
(low-density lipoprotein) particles
against oxidative stresses that can render them more toxic.
CoQ10 also supports healthy blood pressure management, both systolic
and diastolic, as indicated by a 2007 meta-analysis of 12 clinical
trials. In all, CoQ10 nutritionally supports the heart, the
blood vessels and the circulating blood via dual and complementary
molecular action mechanisms.
Breakthrough for the Brain
brain is a tremendous ATP guzzler. At rest, this 3-pound organ uses
about 20 percent of the body’s total energy; when fully engaged it can
consume 50 percent or more.5 Functional brain decline, whether
to toxic nerve cell death, to cumulative age-related damage, or to
hereditary limitations, typically begins with impaired production of ATP
in the zones earliest afflicted.5
Dietary supplementation with CoQ10 has partially slowed brain
decline, and at blood CoQ10 levels that are likely attainable with the
VESIsorb delivery system. In double-blind trials, CoQ10
was helpful against limitations of limb movement and other motor
problems known to be based in the brain.
Supports Immune System Performance
The pioneering CoQ10 researcher Karl Folkers and his colleagues found that CoQ10 supplementation
increased IgG antibody and CD4 T-lymphocyte (“helper cell”) counts in healthy subjects.
Other immune cells (“phagocytes”, “killer cells”) use CoQ10 for
mobility and to generate free radicals directed against their prey. Some
of these cells re-direct the same CoQ10 electron transfer properties
normally used to make energy, into generating highly destructive free
radicals. An Italian study of subjects aged over 90 found that natural
killer cell performance was most impaired in subjects with the worst
CoQ10’s Many Other Proven Benefits Other benefits of CoQ10 as documented from clinical studies include:
• Protection of the gum tissue against oxidative damage
• Improvement in the time to fatigue during aerobic exercise
• Enhanced resistance of the skeletal muscles to damage from intense exercise
• Facilitation of flow-mediated dilation function in the peripheral circulation
• Energetic and antioxidant support for healthy spermatozoa motility
• Improved tolerance of surgical stress
Some of the clinical studies suggest that the greater the degree of
initial CoQ10 deficiency the greater the degree of functional impairment and the greater the degree of subsequent functional improvement once the tissue CoQ10 level is replenished to the normal range.
It is still not clear whether tissue CoQ10 levels always decline with
advancing age. But given that tissue markers of oxidative stress do
increase with age; that CoQ10 is a potent antioxidant that helps
conserve other antioxidants; and that CoQ10 is well tolerated and safe
for long-term use, it would seem prudent for older individuals (or young
individuals with fatigue problems) to take supplemental CoQ10 daily.
Individuals who are vegetarians are also well advised to take
supplemental CoQ10, as are those who take statin drugs or other drugs
known to be oxidative. In the early stages of CoQ10 research, poor
bioavailability was the major factor limiting its efficacy as a dietary
supplement. The advent of the VESIsorb delivery technology now makes
delivery of CoQ10 to the tissues routine, efficient and affordable.
Omega-3 DHA and EPA
CoQ10, the omega-3 nutrients DHA (DocosaHexaenoic Acid) and EPA
(EicosaPentaenoic Acid) are cell membrane building blocks that are both
protective and crucial to the health of the cell as a whole. Like CoQ10,
they operate only in cell membranes, are distributed throughout the
membrane networks, and influence even the innermost core of the
DHA and EPA are anchored into the membrane’s matrix by phospholipid
molecules. The long, electron-dense hydrocarbon chains of these two
fatty acids extend deep into the membrane’s core and help keep that zone
semi-fluid. For optimal membrane function it is essential
to have sufficient omega-3 chains to maintain this semi-fluid state at
all times. The omega-3 chains also allow freedom of movement for CoQ10,
which is confined to the membrane core.
DHA has a longer molecular chain than EPA (22 carbons versus 20 for
EPA), and therefore a greater fluidizing effect on membranes.
EPA is important, however, as a parent source of messenger substances —
prostaglandins and other eicosanoids — that regulate healthy function
(homeostasis) throughout the tissues. Recently it was
established that DHA also is used to make messengers— in this case
docosanoids, also called protectins and resolvins. These
DHA derivatives protect the tissues by helping to limit potentially
harmful immune system over-excitation in response to injury.
There is a huge body of clinical cardiovascular research on DHA and
EPA, mainly as “fish oil” supplements. As with CoQ10, DHA and EPA have a
variety of clinically proven health benefits.
Diverse Circulation Benefits of DHA and EPA
together, the thousands of epidemiologic, observational, experimental
and randomized controlled trials published over the past 3 decades
document clear cardiovascular benefits from omega-3 DHA and EPA. These long-chain omega-3s lower the risk of “adverse” cardiovascular
events by some 19-45 percent, and the shorter-chain ALA (alpha-linolenic
acid) from plants does not substitute for these benefits. Humans convert less than 5% of dietary ALA to EPA (and less to DHA), therefore vegetarians are well advised to take supplemental DHA and EPA as dietary supplements.
The weight of the evidence supporting the benefits of DHA and EPA for
heart and blood vessel health is so great, that in 2003 the American
Heart Association (AHA) made a nutrient endorsement for the first time
in its history. The AHA joined with other professional healthcare
organizations worldwide to issue strong recommendations that individuals
consume DHA and EPA daily for cardiovascular wellbeing. In
2004, the U.S. Food and Drug Administration (FDA) announced it would
“consider exercising enforcement discretion” for a qualified health
claim that consumption of EPA and DHA omega-3 fatty acids may reduce the
risk of coronary heart disease.
DHA and EPA are clearly established to confer their cardiovascular
benefits via their presence in cell membranes. As reviewed by Lee and
colleagues in 2008, their cardiovascular benefits include:
• Increasing the threshold for arrhythmia (that is, lessening the risk for breakdown of the healthy heart rhythm)
• Supporting healthy heart rate variability
• Supporting healthy blood pressure and arterial and endothelial function
• Supporting healthy platelet function
• Favorably affecting autonomic tone (non-conscious nervous control of organ functions).
DHA and EPA can be safely consumed along with statin drugs.
Since statins interfere with the body’s CoQ10 synthesis, supplementing
with VESIsorb CoQ10 Plus Omega-3 would offer a compound advantage to
the statin user: the benefits of DHA and EPA combined with the benefits
of CoQ10 and repletion of CoQ10 lost to the statin therapy.
Brain Benefits From DHA and EPA
the proven benefits of DHA and EPA for the brain are their essentiality
for the pre-and post-natal development of the visual and other sensory
functions, along with the brain’s cognitive functions; for the
maintenance of these functions across the entire lifespan, for healthy
behavior management and for healthy mood control.
Nerve cells are the largest cells of the body. They rely on long
“axon” stretches (up to four feet worth) with their associated membrane
mass to generate, transmit, and integrate the electrical and chemical
signals necessary for normal functions. These membranes are kept semi-fluid by having high omega-3 content.
Epidemiologic studies indicate that when the brain is relatively
deficient in omega-3s, the risk increases for premature deterioration of
memory and the other higher brain functions.
The retinal photoreceptors, nerve-type cells that interface with
nerve cells in the brain to accomplish vision, also rely heavily on the
omega-3s. DHA is more closely linked to good vision than is EPA, and
dietary insufficiency of DHA in early life is linked to poor vision
development as well as relative cognitive impairment. DHA and EPA make up a substantial proportion of the fatty acids in healthy human breast milk.
Mood and behavior are also closely linked to DHA and EPA status (here again, ALA does not effectively substitute). In children, poor omega-3 status predicts higher risk for behavioral unpredictability and learning problems.
Double-blind trials and other clinical experience demonstrate that
children with difficulties of behavior and learning can markedly improve
following supplementation with DHA and EPA. A 2006 meta-analysis by the
American Psychiatric Association found statistically significant
benefit from DHA and EPA for adults with mood problems.
The evidence for brain benefits from DHA and EPA supplementation is
almost as overwhelming as the cardiovascular evidence. Numerous
epidemiologic studies, clinical trials, and other studies show that the
crucial roles of DHA and EPA for brain health begin well before birth
and continue through childhood and adolescence into middle age and late
life. As a rule, the higher the omega-3 levels in the brain, the lower
the risk for dysfunctions of mood, behavior or cognition. For their
significance to intelligence, healthy mood management and appropriate
behavior, the brain benefits of DHA and EPA would seem as important as
their well-established circulation benefits.
Benefits for the Joints and Other Tissues
and EPA support healthy joint flexibility and overall performance,
especially when supplemented in gram quantities daily. A 2007
meta-analysis of 17 randomized, controlled trials found that DHA and EPA
significantly improved (1) joint stiffness, (2) the total number of
painful or tender joints, and (3) the level of joint pain intensity.
Though their benefits for some tissues have been studied more than
others, DHA and EPA actually benefit all the tissues of the body. Proven
benefits for other organ systems include:
• Gastrointestinal: zones
of damage to the lining can respond positively to DHA plus EPA, as shown
in clinical trials. Protective omega-3 eicosanoids and docosanoids help
calm down immune overactivity.
• Gastrointestinal: DHA
and EPA can down-regulate overactive cell proliferation, perhaps via
regulatory effects on genes linked to cell cycle control.
Other: wide-ranging clinical benefits are linked to DHA and EPA
influences on cell signaling and gene expression in many different cell
Dietary intakes of DHA and EPA currently are grossly insufficient in the typical Western diet.
They are virtually absent from food plants, and severely lacking in the
meat produced from farm animals raised in feedlots. This overall
dietary lack contributes to measurable imbalances in the cell membrane
fatty acid ratios, which are linked to sub-optimal membrane fluidity
that compromises metabolic functions. Individuals seeking optimal health are well advised to supplement their daily diet with DHA plus EPA.
It is not easy to construct a natural diet that is adequate in DHA
plus EPA. Wild-caught cold-water fish are a viable source but are
relatively expensive and often polluted with mercury and/or other toxic
residues. Obtaining dietary supplements from reputable suppliers is the
best way to ensure a clean, potent, and affordable daily supply.
VESIsorb CoQ10 Plus Omega-3 combines these three functionally
complementary cell membrane nutrients into one convenient to take,
affordable and highly bioavailable preparation.
In addition to the dramatic improvement of CoQ10 absorption by VESIsorb®, as illustrated in the chart above, data from a preliminary human study suggests that VESIsorb also enhances DHA and EPA absorption.The combination of CoQ10, DHA and EPA into one supplement with
VESIsorb delivery improves their likelihood for universally improving
cell membrane efficiency and in turn for upgrading all the tissues and
Cell membranes are the key to the most fundamental life processes,
which translate into the body’s overall functional readiness and support
optimal health. Considering that CoQ10, DHA and EPA have such
complementary membrane functions, and that deficiencies of these
nutrients can have such wide-ranging negative effects, VESIsorb CoQ10
Plus Omega-3 offers great promise for improving health and wellbeing at